Confocal Microscopy Studies of a Model Oligoribonucleotide HIV Inhibitor.
Robyn M. Hyde, Keith D. Jensen, Jindrich Kopecek, and Arthur D. Broom.
Nucleosides, Nucleotides, and Nucleic Acids, 24, (10-12) 1875-1884 (2005).
[Link to paper]


Previous work has shown that novel amphipathic oligo and polyribonucleotides are potent inhibitors of HIV. It was hypothesized that the mechanism(s) of action for these compounds might be inhibition of retroviral reverse transcriptase (RT) and/or viral uptake by cells. A fluorescent oligonucleotide analog was prepared, and confocal microscopy studies were undertaken in order to examine oligonucleotide-cell interactions.

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